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Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
Napolitano, Valeria; Mróz, Piotr; Marciniak, Monika; Kalel, Vishal C; Softley, Charlotte A; Janna Olmos, Julian D; Tippler, Bettina G; Schorpp, Kenji; Rioton, Sarah; Fröhlich, Tony; Plettenburg, Oliver; Hadian, Kamyar; Erdmann, Ralf; Sattler, Michael; Popowicz, Grzegorz M; Dawidowski, Maciej; Dubin, Grzegorz.
Afiliação
  • Napolitano V; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland. Electronic address: valeria.napolitano@helmholtz-muenchen.de.
  • Mróz P; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland.
  • Marciniak M; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland.
  • Kalel VC; Institute of Biochemistry and Pathobiochemistry, Department of Systems Biochemistry, Faculty of Medicine, Ruhr University Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
  • Softley CA; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, D-85764, Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair of Biomolecular NMR, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85747 Garching, Germany.
  • Janna Olmos JD; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland.
  • Tippler BG; Institute of Biochemistry and Pathobiochemistry, Department of Systems Biochemistry, Faculty of Medicine, Ruhr University Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
  • Schorpp K; Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, D-85764, Neuherberg, Germany.
  • Rioton S; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, D-85764, Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair of Biomolecular NMR, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85747 Garching, Germany.
  • Fröhlich T; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, D-85764, Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair of Biomolecular NMR, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85747 Garching, Germany.
  • Plettenburg O; Institute of Medicinal Chemistry, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, D-85764, Neuherberg, Germany.
  • Hadian K; Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, D-85764, Neuherberg, Germany.
  • Erdmann R; Institute of Biochemistry and Pathobiochemistry, Department of Systems Biochemistry, Faculty of Medicine, Ruhr University Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
  • Sattler M; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, D-85764, Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair of Biomolecular NMR, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85747 Garching, Germany.
  • Popowicz GM; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, D-85764, Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair of Biomolecular NMR, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85747 Garching, Germany.
  • Dawidowski M; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland. Electronic address: maciej.dawidowski@wum.edu.pl.
  • Dubin G; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland. Electronic address: grzegorz.dubin@uj.edu.pl.
Eur J Med Chem ; 243: 114778, 2022 Dec 05.
Article em En | MEDLINE | ID: mdl-36194937
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma / Trypanosoma brucei brucei Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma / Trypanosoma brucei brucei Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article