Elucidation of the binding mechanism of astragaloside IV derivative with human serum albumin and its cardiotoxicity in zebrafish embryos.

Wu, You-Jiao; Li, Zhan-Hua; Li, Jiu-Yan; Zhou, Yan; Wang, Run-Yue; Chen, Xiao-Yi; Qing, Lin-Sen; Luo, Pei

Wu, You-Jiao; Li, Zhan-Hua; Li, Jiu-Yan; Zhou, Yan; Wang, Run-Yue; Chen, Xiao-Yi; Qing, Lin-Sen; Luo, Pei.

Afiliação

Wu YJ; State Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, SAR, China.
Li ZH; State Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, SAR, China.
Li JY; State Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, SAR, China.
Zhou Y; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Wang RY; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Chen XY; State Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, SAR, China.
Qing LS; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Luo P; State Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, SAR, China.

Front Pharmacol ; 13: 987882, 2022.

Article em En | MEDLINE | ID: mdl-36210826

Palavras-chave

UHPLC-MS/MS; astragaloside IV derivative; drug-HSA interaction; equilibrium dialysis; molecular modeling; zebrafish

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China