VaporSPOT: Parallel Synthesis of Oligosaccharides on Membranes.
J Am Chem Soc
; 144(43): 19832-19837, 2022 11 02.
Article
em En
| MEDLINE
| ID: mdl-36269942
ABSTRACT
Automated chemical synthesis has revolutionized synthetic access to biopolymers in terms of simplicity and speed. While automated oligosaccharide synthesis has become faster and more versatile, the parallel synthesis of oligosaccharides is not yet possible. Here, a chemical vapor glycosylation strategy (VaporSPOT) is described that enables the simultaneous synthesis of oligosaccharides on a cellulose membrane solid support. Different linkers allow for flexible and straightforward cleavage, purification, and characterization of the target oligosaccharides. This method is the basis for the development of parallel automated glycan synthesis platforms.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Alemanha