Improved Outcomes in Severe Primary Graft Dysfunction After Heart Transplantation Following Donation After Circulatory Death Compared With Donation After Brain Death.
J Card Fail
; 29(1): 67-75, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36351494
ABSTRACT
BACKGROUND:
Primary graft dysfunction (PGD), the leading cause of early mortality after heart transplantation, is more common following donation after circulatory death (DCD) than donation after brain death (DBD). We conducted a single-center, retrospective cohort study to compare the incidence, severity and outcomes of patients experiencing PGD after DCD compared to DBD heart transplantation. METHODS ANDRESULTS:
Medical records were reviewed for all adult heart transplant recipients at our institution between March 2016 and December 2021. PGD was diagnosed within 24 hours after transplant according to modified International Society for Heart and Lung Transplant criteria. A total of 459 patients underwent isolated heart transplantation during the study period, 65 (14%) following DCD and 394 (86%) following DBD. The incidence of moderate or severe PGD in DCD and DBD recipients was 34% and 23%, respectively (Pâ¯=â¯0.070). DCD recipients were more likely to experience severe biventricular PGD than DBD recipients (19% vs 7.4%; Pâ¯=â¯0.004). Among patients with severe PGD, DCD recipients experienced shorter median (Q1, Q3) duration of post-transplant mechanical circulatory support (6 [4, 7] vs 9 [5, 14] days; Pâ¯=â¯0.039), shorter median post-transplant hospital length of stay (17 [15, 29] vs 52 [26, 83] days; Pâ¯=â¯0.004), and similar 60-day survival rates (100% [95% CI 76.8%-100%] vs 80.0% [63.1%-91.6%]; Pâ¯=â¯0.17) and overall survival (log-rank; Pâ¯=â¯0.078) compared with DBD recipients.CONCLUSIONS:
DCD heart transplant recipients were more likely to experience severe, biventricular PGD than DBD recipients. Despite this, DCD recipients with severe PGD spent fewer days on mechanical circulatory support and in the hospital than similar DBD patients. These findings suggest that patterns of graft dysfunction and recovery may differ between donor types, and they support the expansion of the heart-donor pool with DCD.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Obtenção de Tecidos e Órgãos
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Transplante de Coração
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Disfunção Primária do Enxerto
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Insuficiência Cardíaca
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
J Card Fail
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Nova Caledônia