Insulin Signaling Disruption and INF-Î³ Upregulation Induce Aß<sub>1-42</sub> and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells.

Abascal, Maria Luisa; Sanjuan, Javier; Moyano, Paula; Sola, Emma; Flores, Andrea; Garcia, José Manuel; Garcia, Jimena; Frejo, María Teresa; Del Pino, Javier

Insulin Signaling Disruption and INF-Î³ Upregulation Induce Aß_1-42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells.

Abascal, Maria Luisa; Sanjuan, Javier; Moyano, Paula; Sola, Emma; Flores, Andrea; Garcia, José Manuel; Garcia, Jimena; Frejo, María Teresa; Del Pino, Javier.

Afiliação

Abascal ML; Department of Pathology, Gregorio Marañon Hospital, 28007 Madrid, Spain.
Sanjuan J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Sola E; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Flores A; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Garcia JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Garcia J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.

Chem Res Toxicol ; 35(12): 2214-2218, 2022 12 19.

Article em En | MEDLINE | ID: mdl-36394833

Assuntos

Paraquat; Proteínas tau; Proteínas tau/metabolismo; Paraquat/toxicidade; Paraquat/metabolismo; Secretases da Proteína Precursora do Amiloide/metabolismo; Secretases da Proteína Precursora do Amiloide/farmacologia; Glicogênio Sintase Quinase 3 beta/metabolismo; Glicogênio Sintase Quinase 3 beta/farmacologia; Insulina/metabolismo; Regulação para Cima; Ácido Aspártico Endopeptidases/metabolismo; Ácido Aspártico Endopeptidases/farmacologia; Peptídeos beta-Amiloides/metabolismo; Hipocampo; Morte Celular

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Paraquat / Proteínas tau Idioma: En Revista: Chem Res Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha

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