Cytoophidia safeguard binucleation of Drosophila male accessory gland cells.
Exp Cell Res
; 422(1): 113433, 2023 01 01.
Article
em En
| MEDLINE
| ID: mdl-36423659
ABSTRACT
Although most cells are mononuclear, the nucleus can exist in the form of binucleate or even multinucleate to respond to different physiological processes. The male accessory gland of Drosophila is the organ that produces semen, and its main cells are binucleate. Here we observe that CTP synthase (CTPS) forms filamentous cytoophidia in binuclear main cells, primarily located at the cell boundary. In CTPSH355A, a point mutation that destroys the formation of cytoophidia, we find that the nucleation mode of the main cells changes, including mononucleates and vertical distribution of binucleates. Although the overexpression of CTPSH355A can restore the level of CTPS protein, it will neither form cytoophidia nor eliminate the abnormal nucleation pattern. Therefore, our data indicate that there is an unexpected functional link between the formation of cytoophidia and the maintenance of binucleation in Drosophila main cells.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Carbono-Nitrogênio Ligases
/
Drosophila
Limite:
Animals
Idioma:
En
Revista:
Exp Cell Res
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China