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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Huang, Wei-Sheng; Li, Feng; Gong, Yongjin; Zhang, Yun; Youngsaye, Willmen; Xu, Yongjin; Zhu, Xiaotian; Greenfield, Matthew T; Kohlmann, Anna; Taslimi, Paul M; Toms, Angela; Zech, Stephan G; Zhou, Tianjun; Das, Biplab; Jang, Hyun G; Tugnait, Meera; Ye, Yihua E; Gonzalvez, Francois; Baker, Theresa E; Nadworny, Sara; Ning, Yaoyu; Wardwell, Scott D; Zhang, Sen; Gould, Alexandra E; Hu, Yongbo; Lane, Weston; Skene, Robert J; Zou, Hua; Clackson, Tim; Narasimhan, Narayana I; Rivera, Victor M; Dalgarno, David C; Shakespeare, William C.
Afiliação
  • Huang WS; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States. Electronic address: weisheng.huang@theseusrx.com.
  • Li F; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Gong Y; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Zhang Y; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Youngsaye W; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Xu Y; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Zhu X; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Greenfield MT; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Kohlmann A; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Taslimi PM; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Toms A; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Zech SG; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Zhou T; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Das B; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Jang HG; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Tugnait M; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Ye YE; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Gonzalvez F; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Baker TE; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Nadworny S; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Ning Y; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Wardwell SD; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Zhang S; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Gould AE; Takeda Development Center Americas, Inc, 95 Hayden Avenue, Lexington, MA 02421, United States.
  • Hu Y; Takeda Development Center Americas, Inc, 95 Hayden Avenue, Lexington, MA 02421, United States.
  • Lane W; Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 45 Landsdowne Street, Cambridge, MA 02139, United States.
  • Skene RJ; Takeda Development Center Americas, Inc, 95 Hayden Avenue, Lexington, MA 02421, United States.
  • Zou H; Takeda Development Center Americas, Inc, 95 Hayden Avenue, Lexington, MA 02421, United States.
  • Clackson T; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Narasimhan NI; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Rivera VM; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Dalgarno DC; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
  • Shakespeare WC; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.
Bioorg Med Chem Lett ; 80: 129084, 2023 01 15.
Article em En | MEDLINE | ID: mdl-36423823
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article