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Cervical Microbiome in Women Infected with HPV16 and High-Risk HPVs.
Sasivimolrattana, Thanayod; Chantratita, Wasun; Sensorn, Insee; Chaiwongkot, Arkom; Oranratanaphan, Shina; Bhattarakosol, Pattarasinee; Bhattarakosol, Parvapan.
Afiliação
  • Sasivimolrattana T; Medical Microbiology Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.
  • Chantratita W; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
  • Sensorn I; Center for Medical Genomics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
  • Chaiwongkot A; Center for Medical Genomics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
  • Oranratanaphan S; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
  • Bhattarakosol P; Division of Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
  • Bhattarakosol P; Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Article em En | MEDLINE | ID: mdl-36429432
ABSTRACT
Human papillomavirus type 16 (HPV16) and/or high-risk (Hr-) HPV are the main causes of cervical cancer. Another element that may contribute to the development of cervical cancer is the microbiota. To date, no study has investigated the entire cervical microbiome, which consists of bacteria, fungi, and viruses. In this study, cervical samples with different histopathology (CIN1, CIN2, and CIN3), with or without HPV16 and Hr-HPVs infection, were enrolled. From bacterial community analysis, 115 bacterial species were found and separated into 2 distinct categories based on Lactobacillus abundance Lactobacilli-dominated (LD) and non-Lactobacilli-dominated (NLD) groups. The LD group had significantly less bacterial diversity than the NLD group. In addition, the variety of bacteria was contingent on the prevalence of HPV infection. Among distinct histological groups, an abundance of L. iners (>60% of total Lactobacillus spp.) was discovered in both groups. A few fungi, e.g., C. albicans, were identified in the fungal community. The viral community analysis revealed that the presence of HPV considerably reduced the diversity of human viruses. Taken together, when we analyzed all our results collectively, we discovered that HPV infection was a significant determinant in the diversity of bacteria and human viruses in the cervix.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Displasia do Colo do Útero / Neoplasias do Colo do Útero / Infecções por Papillomavirus / Microbiota Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Int J Environ Res Public Health Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Tailândia

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Displasia do Colo do Útero / Neoplasias do Colo do Útero / Infecções por Papillomavirus / Microbiota Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Int J Environ Res Public Health Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Tailândia