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A 3D stack-of-spirals approach for rapid hyperpolarized 129 Xe ventilation mapping in pediatric cystic fibrosis lung disease.
Zanette, Brandon; Munidasa, Samal; Friedlander, Yonni; Ratjen, Felix; Santyr, Giles.
Afiliação
  • Zanette B; Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Munidasa S; Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Friedlander Y; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Ratjen F; Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Santyr G; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Magn Reson Med ; 89(3): 1083-1091, 2023 03.
Article em En | MEDLINE | ID: mdl-36433705
ABSTRACT

PURPOSE:

To demonstrate the feasibility of a rapid 3D stack-of-spirals (3D-SoS) imaging acquisition for hyperpolarized 129 Xe ventilation mapping in healthy pediatric participants and pediatric cystic fibrosis (CF) participants, in comparison to conventional Cartesian multislice (2D) gradient-recalled echo (GRE) imaging.

METHODS:

The 2D-GRE and 3D-SoS acquisitions were performed in 13 pediatric participants (5 healthy, 8 CF) during separate breath-holds. Images from both sequences were compared on the basis of ventilation defect percent (VDP) and other measures of image similarity. The nadir of transient oxygen saturation (SpO2 ) decline due to xenon breath-holding was measured with pulse oximetry, and expressed as a percent change relative to baseline.

RESULTS:

129 Xe ventilation images were acquired in a breath-hold of 1.2-1.8 s with the 3D-SoS sequence, compared to 6.2-8.8 s for 2D-GRE. Mean ± SD VDP measures for 2D-GRE and 3D-SoS sequences were 5.02 ± 1.06% and 5.28 ± 1.08% in healthy participants, and 18.05 ± 8.26% and 18.75 ± 6.74% in CF participants, respectively. Across all participants, the intraclass correlation coefficient of VDP measures for both sequences was 0.98 (95% confidence interval 0.94-0.99). The percent change in SpO2 was reduced to -2.1 ± 2.7% from -5.2 ± 3.5% with the shorter 3D-SoS breath-hold.

CONCLUSION:

Hyperpolarized 129 Xe ventilation imaging with 3D-SoS yielded images approximately five times faster than conventional 2D-GRE, reducing SpO2 desaturation and improving tolerability of the xenon administration. Analysis of VDP and other measures of image similarity demonstrate excellent agreement between images obtained with both sequences. 3D-SoS holds significant potential for reducing the acquisition time of hyperpolarized 129 Xe MRI, and/or increasing spatial resolution while adhering to clinical breath-hold constraints.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Transtornos Respiratórios / Fibrose Cística Limite: Child / Humans Idioma: En Revista: Magn Reson Med Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Transtornos Respiratórios / Fibrose Cística Limite: Child / Humans Idioma: En Revista: Magn Reson Med Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá