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KETO[18F]FDG -VAP-P1: In vivo studies of a potential PET radiotracer for diagnosis of inflammation.
Faria Almeida, Fernanda Aparecida de; Almeida Schirmer, Brígida G de; de Oliveira Silva, Juliana; de Araújo Bispo, Ana Carolina; Melo Mendes, Bruno; Vidal Ferreira, Andrea; Batista Silva, Juliana; Mamede, Marcelo.
Afiliação
  • Faria Almeida FA; Radiopharmaceutical Research and Production Unit, Nuclear Technology Development Center, Belo Horizonte, Brazil. Electronic address: nanda10a@gmail.com.
  • Almeida Schirmer BG; Radiopharmaceutical Research and Production Unit, Nuclear Technology Development Center, Belo Horizonte, Brazil.
  • de Oliveira Silva J; Radiopharmaceutical Research and Production Unit, Nuclear Technology Development Center, Belo Horizonte, Brazil.
  • de Araújo Bispo AC; Radiopharmaceutical Research and Production Unit, Nuclear Technology Development Center, Belo Horizonte, Brazil.
  • Melo Mendes B; Radiopharmaceutical Research and Production Unit, Nuclear Technology Development Center, Belo Horizonte, Brazil.
  • Vidal Ferreira A; Radiopharmaceutical Research and Production Unit, Nuclear Technology Development Center, Belo Horizonte, Brazil.
  • Batista Silva J; Radiopharmaceutical Research and Production Unit, Nuclear Technology Development Center, Belo Horizonte, Brazil.
  • Mamede M; Anatomy and Imaging Department, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Appl Radiat Isot ; 192: 110547, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36470157
ABSTRACT
The biodistribution of radiotracer peptide KETO[18F]FDG-VAP-P1 was evaluated by ex vivo radiation count in organs and in vivo PET imaging of healthy mice. The peptide was quickly eliminated by the kidneys. The local inflammation caused by a sterile polyurethane sponge was evaluated by PET images. In addition, dosimetry estimates of KETO[18F]FDG-VAP-P1 tracer are determined for mice using Monte Carlo simulations. Thus, the results of this study indicate that KETO[18F]FDG-VAP-P1 is a potential radiotracer for inflammation imaging.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fluordesoxiglucose F18 / Inflamação Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Appl Radiat Isot Assunto da revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fluordesoxiglucose F18 / Inflamação Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Appl Radiat Isot Assunto da revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Ano de publicação: 2023 Tipo de documento: Article