Piperine Attenuates Cigarette Smoke-Induced Oxidative Stress, Lung Inflammation, and Epithelial-Mesenchymal Transition by Modulating the SIRT1/Nrf2 Axis.

Saha, Pritam; Durugkar, Sneha; Jain, Siddhi; Shantanu, P A; Panda, Samir R; Jala, Aishwarya; Gokhale, Sharad; Sharma, Pawan; Naidu, V G M

Saha, Pritam; Durugkar, Sneha; Jain, Siddhi; Shantanu, P A; Panda, Samir R; Jala, Aishwarya; Gokhale, Sharad; Sharma, Pawan; Naidu, V G M.

Afiliação

Saha P; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Changsari, Guwahati 781101, Assam, India.
Durugkar S; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Changsari, Guwahati 781101, Assam, India.
Jain S; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Changsari, Guwahati 781101, Assam, India.
Shantanu PA; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Changsari, Guwahati 781101, Assam, India.
Panda SR; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Changsari, Guwahati 781101, Assam, India.
Jala A; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research Guwahati, Changsari, Guwahati 781101, Assam, India.
Gokhale S; Department of Civil Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Sharma P; Division of Pulmonary, Allergy and Critical Care Medicine, Centre for Translational Medicine, Jane & Leonard Korman Respiratory Institute, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Naidu VGM; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Changsari, Guwahati 781101, Assam, India.

Int J Mol Sci ; 23(23)2022 Nov 25.

Article em En | MEDLINE | ID: mdl-36499047

Assuntos

Transição Epitelial-Mesenquimal; Piperidinas; Pneumonia; Fumaça; Animais; Camundongos; Antioxidantes/farmacologia; Pulmão/patologia; Camundongos Endogâmicos BALB C; Fator 2 Relacionado a NF-E2/genética; Estresse Oxidativo; Pneumonia/tratamento farmacológico; Pneumonia/patologia; Sirtuína 1/genética; Nicotiana/efeitos adversos; Fumaça/efeitos adversos; Piperidinas/farmacologia

Palavras-chave

EMT; airway disease; antioxidant; cigarette smoke; inflammation; piperine

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piperidinas / Pneumonia / Fumaça / Transição Epitelial-Mesenquimal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

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