Chloroquine prevents hypoxic accumulation of HIF-1&#945; by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.

Kang, Changyu; Ju, Sanghyun; Kim, Jaejeong; Jung, Yunjin

Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.

Kang, Changyu; Ju, Sanghyun; Kim, Jaejeong; Jung, Yunjin.

Afiliação

Kang C; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Ju S; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Kim J; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Jung Y; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea. jungy@pusan.ac.kr.

Pharmacol Rep ; 75(1): 211-221, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36508076

Assuntos

Carcinoma; Neoplasias do Colo; Humanos; Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Hipóxia Celular; Linhagem Celular Tumoral; Cloroquina/farmacologia; Neoplasias do Colo/metabolismo; Fluoruracila; Hipóxia/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

5-Fluorouracil; Ataxia telangiectasia and Rad3-related kinase; Chemosensitization; Chloroquine; Colorectal cancer; Hypoxia-inducible factor

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Carcinoma / Neoplasias do Colo Limite: Humans Idioma: En Revista: Pharmacol Rep Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article

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