Positive effects of ketogenic diet on weight control in children with obesity due to Prader-Willi syndrome.
Clin Endocrinol (Oxf)
; 98(3): 332-341, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36536479
ABSTRACT
OBJECTIVE:
Prader-Willi Syndrome (PWS) is the most common genetic cause of obesity. Prevention and management of obesity, which represents the main cause of morbidity and mortality in these patients, is essential. Ketogenic diet (KD) is used in the treatment of various disorders, however knowledge of its effect in PWS is lacking. The present study assesses the characteristics of patients with PWS who were on KD. DESIGN AND PATIENTS This is a retrospective, cross-sectional descriptive study investigating the subjects with PWS, who had received KD for at least 6 months.RESULTS:
Ten patients with PWS [median age 52.5 (47-77) months] complied with KD. The median treatment period was 16.5 [11-52] months. Of the daily calorie, 75%-85% were from fat, and 15%-25% from protein + carbohydrate. The baseline body weight standard deviation (SD) score before diet therapy was 2.10 [-1.11-4.11], whereas it was 0.05 [-0.92-1.2] at final evaluation (p = .007). The baseline median BMI SD score before diet therapy was 3.05 [-0.21-3.72], whereas it was 0.41 [-0.87-1.57] at final evaluation (p = .002). The height SD score remained unchanged. Mild hypercholesterolaemia was the most common biochemical abnormality during treatment with KD.CONCLUSION:
Our results indicate that KD might have a favourable effect on weight management in PWS.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Síndrome de Prader-Willi
/
Dieta Cetogênica
Limite:
Child
/
Humans
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Middle aged
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Turquia