Oligoclonal IgM bands are a promising biomarker for long-term cognitive outcomes in multiple sclerosis.
Mult Scler Relat Disord
; 68: 104397, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-36544326
ABSTRACT
BACKGROUND:
The presence of lipid-specific oligoclonal IgM bands (LS-OCMB) in cerebrospinal fluid is associated with a more severe clinical multiple sclerosis (MS) course.OBJECTIVE:
To investigate LS-OCMB as a prognostic biomarker of cognitive long-term outcomes in MS.METHODS:
Ninety-nine patients underwent neuropsychological assessment. Cognitive performance between LS-OCMB- and LS-OCMB+ patients was compared adjusting by age, education, anxiety-depression, disease duration, and disability.RESULTS:
LS-OCMB+ patients of â¼13 years of disease duration performed worse on Symbol Digit Modalities Test (SDMT) (p = 0.005).CONCLUSION:
LS-OCMB+ perform worse on information processing speed and working memory (SDMT), suggesting that LS-OCMB could be a useful biomarker for long-term cognitive outcomes.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Esclerose Múltipla
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Mult Scler Relat Disord
Ano de publicação:
2022
Tipo de documento:
Article