State of art in the chemistry of nucleoside-based Pt(II) complexes.
Bioorg Chem
; 131: 106325, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-36577221
ABSTRACT
After the fortuitous discovery of the anticancer properties of cisplatin, many Pt(II) complexes have been synthesized, to obtain less toxic leads which could overcome the resistance phenomena. Given the importance of nucleosides and nucleotides as antimetabolites, studying their coordinating properties towards Pt(II) ions is challenging for bioorganic and medicinal chemistry. This review aims to describe the results achieved so far in the aforementioned field, paying particular attention to the synthetic aspects, the chemical-physical characterization, and the biological activities of the nucleoside-based Pt(II) complexes.
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Bases de dados:
MEDLINE
Assunto principal:
Compostos de Platina
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Complexos de Coordenação
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Antineoplásicos
Idioma:
En
Revista:
Bioorg Chem
Ano de publicação:
2023
Tipo de documento:
Article