Dysregulation of complement factor H in juvenile-onset systemic lupus erythematosus patients.
Arch Rheumatol
; 37(3): 417-423, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-36589613
ABSTRACT
Objectives:
This study aims to evaluate the expression pattern of factor H in peripheral blood and the frequency of factor H autoantibodies in plasma of juvenile-onset systemic lupus erythematosus (jSLE) patients compared to healthy controls. Patients andmethods:
Between March 2019 and October 2019, a total of 30 healthy individuals (3 males, 27 females; mean age 26±7.4 years; range, 18 to 40 years) and 65 jSLE patients (age of onset ≤16 years) (2 males, 63 females; mean age 23.4±7 years; range, 15 to 38 years) were included. Factor H expression pattern was examined in blood of all subjects using quantitative real-time polymerase chain reaction and the frequency of factor H autoantibodies was estimated in plasma using enzyme-linked immunosorbent assay.Results:
Factor H expression was significantly downregulated in jSLE patients compared to healthy controls (p<0.01). A significant underexpression of factor H was observed in jSLE patients with nephritis compared to those without nephritis (p<0.03), while there was no association of factor H expression levels with any of the other clinical and serological features, disease activity or disease damage index of patients. Only 5% of jSLE patients were positive for factor H autoantibodies without any correlations with the clinical data or disease activity of patients.Conclusion:
Our study results suggest that factor H expression can be dysregulated in jSLE patients.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Arch Rheumatol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Egito