Efficacy of intra-arterial lidocaine administration on pain and inflammatory response after uterine artery embolization for symptomatic fibroids.
Acta Radiol
; 65(3): 302-306, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-36600596
ABSTRACT
BACKGROUND:
There have been conflicting outcomes regarding the use of lidocaine to reduce pain after uterine artery embolization (UAE).PURPOSE:
To investigate the efficacy of intra-arterial lidocaine injection for pain and inflammatory response control within 24â h of UAE for symptomatic uterine fibroids. MATERIAL ANDMETHODS:
Of 1530 patients who underwent UAE for uterine fibroids in 2007-2021, 5â mL of 1% lidocaine was injected into each uterine artery immediately after UAE in 23 patients. A disease-matched control group (n = 23) who did not receive intra-arterial lidocaine was generated from the same registry. The pain score, white blood cell (WBC) count, C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR), and fentanyl consumption were compared before and after UAE. Complete infarction of the dominant fibroid was assessed using magnetic resonance imaging.RESULTS:
Significantly lower WBC count, CRP level, and NLR were noted 24â h after UAE in the lidocaine group. No statistically significant difference was noted in the pain score between groups at 0-24â h. The cumulative fentanyl dose administered during the first 24â h after UAE was not significantly different. After embolization, fibroid-related symptoms resolved in all patients. No significant difference was observed in the rate of complete infarction of the dominant fibroid.CONCLUSION:
Lidocaine administration immediately after UAE resulted in a significant reduction in the inflammatory response. However, such a difference in the inflammatory reaction did not contribute to significant reductions in pain scores or fentanyl consumption.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Uterinas
/
Embolização da Artéria Uterina
/
Leiomioma
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Acta Radiol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Arábia Saudita