Pulmonary fibrosis in primary Sjögren syndrome: computed tomography, clinical features, and associated clinical factors.
Pol Arch Intern Med
; 133(2)2023 02 27.
Article
em En
| MEDLINE
| ID: mdl-36601871
ABSTRACT
INTRODUCTION:
Interstitial lung disease (ILD) is common in patients with primary Sjögren syndrome (pSS). Pulmonary fibrosis significantly reduces the patient's quality of life. Therefore, better understanding of the characteristics of patients with pulmonary fibrosis is necessary.OBJECTIVES:
The aim of the study was to evaluate the computed tomography (CT) and clinical features of pSSrelated ILD and to explore the factors associated with fibrotic ILD in patients with pSS. PATIENTS ANDMETHODS:
In total, 151 patients with pSSrelated ILD were retrospectively studied for their demographic and clinical characteristics. The patients were categorized into the nonfibrosing ILD and fibrosing ILD groups based on their CT findings. The clinicl, laboratory, and CT findings from both groups were compared to determine the influencing factors associated with the condition.RESULTS:
The nonfibrosing ILD and fibrosing ILD groups comprised 103 and 48 patients, respectively. As compared with the nonfibrosing ILD group, the fibrosing ILD group had a shorter disease duration, higher frequency of dry cough and shortness of breath, more patients with groundglass opacity, mediastinal lymph node disease, and pleural lesions on chest CT, and lower frequency of dry mouth and eyes. Dry cough and shortness of breath were independent predictors of pulmonary fibrosis in the patients with pSS (P = 0.01 and P = 0.02, respectively).CONCLUSIONS:
The presence of dry cough and shortness of breath in the patients with pSS may indicate concomitant pulmonary fibrosis. Highresolution chest CT can be used for better insights on the occurrence and severity of pulmonary fibrosis in these patients.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fibrose Pulmonar
/
Síndrome de Sjogren
/
Doenças Pulmonares Intersticiais
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Pol Arch Intern Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China