Pentoxifylline and thiamine ameliorate rhabdomyolysis-induced acute kidney injury in rats via suppressing TLR4/NF-&#954;B and NLRP-3/caspase-1/gasdermin mediated-pyroptosis.

Al-Kharashi, Layla; Attia, Hala; Alsaffi, Aljazzy; Almasri, Toka; Arafa, Maha; Hasan, Iman; Alajami, Hanaa; Ali, Rehab; Badr, Amira

Pentoxifylline and thiamine ameliorate rhabdomyolysis-induced acute kidney injury in rats via suppressing TLR4/NF-κB and NLRP-3/caspase-1/gasdermin mediated-pyroptosis.

Al-Kharashi, Layla; Attia, Hala; Alsaffi, Aljazzy; Almasri, Toka; Arafa, Maha; Hasan, Iman; Alajami, Hanaa; Ali, Rehab; Badr, Amira.

Afiliação

Al-Kharashi L; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
Attia H; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia; Department of Biochemistry, College of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: hsalem@ksu.edu.sa.
Alsaffi A; College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
Almasri T; College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
Arafa M; Pathology Department, College of Medicine, King Saud University, Riyadh 11495, Saudi Arabia.
Hasan I; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
Alajami H; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
Ali R; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
Badr A; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia; Department of Pharmacology and Toxicology, College of Pharmacy, Ain Shams, University, Heliopolis, Cairo, Egypt.

Toxicol Appl Pharmacol ; 461: 116387, 2023 02 15.

Article em En | MEDLINE | ID: mdl-36690085

Assuntos

Injúria Renal Aguda; Pentoxifilina; Rabdomiólise; Animais; Masculino; Ratos; Injúria Renal Aguda/tratamento farmacológico; Injúria Renal Aguda/etiologia; Injúria Renal Aguda/prevenção & controle; Antioxidantes; Caspase 1/metabolismo; Creatinina; Gasderminas; Glicerol; NF-kappa B/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Proteínas NLR/metabolismo; Pentoxifilina/farmacologia; Pentoxifilina/uso terapêutico; Piroptose/fisiologia; Ratos Wistar; Rabdomiólise/complicações; Rabdomiólise/tratamento farmacológico; Tiamina; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Acute kidney injury; Caspase-1; Gasdermin D; NLRP-3 inflammasome; Pyroptosis; Rhabdomyolysis; TLR-4

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Pentoxifilina / Rabdomiólise / Injúria Renal Aguda Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Arábia Saudita

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