Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment.
Mol Psychiatry
; 28(5): 1902-1918, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36690793
ABSTRACT
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired functioning associated with the disorder and are not responsive to existing treatments. In this review, we first describe the clinical presentation and natural history of these deficits. We then consider aetiological factors, highlighting how a range of similar genetic and environmental factors are associated with both cognitive function and schizophrenia. We then review the pathophysiological mechanisms thought to underlie cognitive symptoms, including the role of dopamine, cholinergic signalling and the balance between GABAergic interneurons and glutamatergic pyramidal cells. Finally, we review the clinical management of cognitive impairments and candidate novel treatments.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Transtornos Cognitivos
/
Disfunção Cognitiva
Limite:
Humans
Idioma:
En
Revista:
Mol Psychiatry
Assunto da revista:
BIOLOGIA MOLECULAR
/
PSIQUIATRIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido