Perinatal inflammation exposure and developmental outcomes 7 years after neonatal arterial ischaemic stroke.
Dev Med Child Neurol
; 65(8): 1073-1080, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-36700522
ABSTRACT
AIM:
To test the association between perinatal inflammation exposure and Full-Scale IQ (FSIQ) score 7 years after neonatal arterial ischaemic stroke (NAIS).METHOD:
We conducted a cross-sectional ancillary study nested in a multicentric longitudinal French cohort of infants born at term with NAIS between November 2003 and October 2006. Seventy-three children were included (45 males, 28 females). The a priori defined primary outcome measure was the FSIQ score assessed with the Wechsler Intelligence Scale for Children, Fourth Edition at 7 years of age.RESULTS:
Seventeen (23%) of the included children were exposed to perinatal inflammation. Exposure to perinatal inflammation was independently associated with an increase of FSIQ score (coefficient 13.4, 95% confidence interval 1.3-25.4; p = 0.03). Children exposed to perinatal inflammation had a higher median cerebral volume, a lower median lesion volume, and less extensive lesion distributions compared to non-exposed children.INTERPRETATION:
We propose the existence of two NAIS categories arteritis-associated NAIS in children exposed to perinatal inflammation and embolism-associated NAIS in children non-exposed to perinatal inflammation. Identifying these two NAIS categories would open the possibility for specific curative strategies anti-inflammatory strategy in arteritis-associated NAIS and recanalization strategy in embolism-associated NAIS.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Arterite
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Isquemia Encefálica
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Acidente Vascular Cerebral
/
AVC Isquêmico
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
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Female
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Humans
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Infant
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Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Dev Med Child Neurol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
França