Protective Effect of Avenanthramide-C on Auditory Hair Cells against Oxidative Stress, Inflammatory Cytokines, and DNA Damage in Cisplatin-Induced Ototoxicity.

Umugire, Alphonse; Nam, Yoon Seok; Nam, Ye Eun; Choi, Young Mi; Choi, Se Myeong; Lee, Sungsu; Cho, Jong Hyun; Cho, Hyong-Ho

Umugire, Alphonse; Nam, Yoon Seok; Nam, Ye Eun; Choi, Young Mi; Choi, Se Myeong; Lee, Sungsu; Cho, Jong Hyun; Cho, Hyong-Ho.

Afiliação

Umugire A; Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.
Nam YS; Department of Biomedical Science, College of Medicine, Chonnam National University Graduate School, Gwangju 61469, Republic of Korea.
Nam YE; BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Gwangju 61469, Republic of Korea.
Choi YM; Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.
Choi SM; Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Republic of Korea.
Lee S; Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.
Cho JH; Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Republic of Korea.
Cho HH; Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.

Int J Mol Sci ; 24(3)2023 Feb 02.

Article em En | MEDLINE | ID: mdl-36769271

Assuntos

Antineoplásicos; Perda Auditiva; Ototoxicidade; Camundongos; Animais; Cisplatino/toxicidade; Cisplatino/metabolismo; Citocinas/metabolismo; Antineoplásicos/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Ototoxicidade/etiologia; Ototoxicidade/metabolismo; Interleucina-6/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Ciclo-Oxigenase 2/metabolismo; Linhagem Celular; Apoptose; Células Ciliadas Auditivas/metabolismo; Estresse Oxidativo; Perda Auditiva/induzido quimicamente; Perda Auditiva/prevenção & controle; Perda Auditiva/metabolismo; Dano ao DNA

Palavras-chave

DNA damage; ROS; avenanthramide-C; cisplatin; hair cell loss; hearing loss

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ototoxicidade / Perda Auditiva / Antineoplásicos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article

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