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Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.
Zhou, Wei; Kanai, Masahiro; Wu, Kuan-Han H; Rasheed, Humaira; Tsuo, Kristin; Hirbo, Jibril B; Wang, Ying; Bhattacharya, Arjun; Zhao, Huiling; Namba, Shinichi; Surakka, Ida; Wolford, Brooke N; Lo Faro, Valeria; Lopera-Maya, Esteban A; Läll, Kristi; Favé, Marie-Julie; Partanen, Juulia J; Chapman, Sinéad B; Karjalainen, Juha; Kurki, Mitja; Maasha, Mutaamba; Brumpton, Ben M; Chavan, Sameer; Chen, Tzu-Ting; Daya, Michelle; Ding, Yi; Feng, Yen-Chen A; Guare, Lindsay A; Gignoux, Christopher R; Graham, Sarah E; Hornsby, Whitney E; Ingold, Nathan; Ismail, Said I; Johnson, Ruth; Laisk, Triin; Lin, Kuang; Lv, Jun; Millwood, Iona Y; Moreno-Grau, Sonia; Nam, Kisung; Palta, Priit; Pandit, Anita; Preuss, Michael H; Saad, Chadi; Setia-Verma, Shefali; Thorsteinsdottir, Unnur; Uzunovic, Jasmina; Verma, Anurag; Zawistowski, Matthew; Zhong, Xue.
Afiliação
  • Zhou W; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Kanai M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Wu KH; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Rasheed H; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Tsuo K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Hirbo JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Wang Y; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Bhattacharya A; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Zhao H; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • Namba S; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • Surakka I; Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway.
  • Wolford BN; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Lo Faro V; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Lopera-Maya EA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Läll K; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Favé MJ; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Partanen JJ; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Chapman SB; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Karjalainen J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kurki M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Maasha M; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Brumpton BM; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Chavan S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Chen TT; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Daya M; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • Ding Y; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • Feng YA; University of Groningen, UMCG, Department of Ophthalmology, Groningen, the Netherlands.
  • Guare LA; Department of Clinical Genetics, Amsterdam University Medical Center (AMC), Amsterdam, the Netherlands.
  • Gignoux CR; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Graham SE; University of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands.
  • Hornsby WE; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Ingold N; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Ismail SI; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Johnson R; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Laisk T; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lin K; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Lv J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Millwood IY; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Moreno-Grau S; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Nam K; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Palta P; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Pandit A; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Preuss MH; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Saad C; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Setia-Verma S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Thorsteinsdottir U; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Uzunovic J; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Verma A; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • Zawistowski M; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
  • Zhong X; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Cell Genom ; 2(10): 100192, 2022 Oct 12.
Article em En | MEDLINE | ID: mdl-36777996
ABSTRACT
Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWASs generated using harmonized genotypes and phenotypes from member biobanks for 14 exemplar diseases and endpoints. This strategy validates that GWASs conducted in diverse biobanks can be integrated despite heterogeneity in case definitions, recruitment strategies, and baseline characteristics. This collaborative effort improves GWAS power for diseases, benefits understudied diseases, and improves risk prediction while also enabling the nomination of disease genes and drug candidates by incorporating gene and protein expression data and providing insight into the underlying biology of human diseases and traits.
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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prognostic_studies / Systematic_reviews Idioma: En Revista: Cell Genom Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prognostic_studies / Systematic_reviews Idioma: En Revista: Cell Genom Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos