Treatment with semaglutide, a GLP-1 receptor agonist, improves extracellular matrix remodeling in the pancreatic islet of diet-induced obese mice.

Cardoso, Luiz E M; Marinho, Thatiany Souza; Martins, Fabiane Ferreira; Aguila, Marcia Barbosa; Mandarim-de-Lacerda, Carlos A

Cardoso, Luiz E M; Marinho, Thatiany Souza; Martins, Fabiane Ferreira; Aguila, Marcia Barbosa; Mandarim-de-Lacerda, Carlos A.

Afiliação

Cardoso LEM; Laboratory of Morphometry, Metabolism, and Cardiovascular disease, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: luizemcardoso@gmail.com.
Marinho TS; Laboratory of Morphometry, Metabolism, and Cardiovascular disease, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Martins FF; Laboratory of Morphometry, Metabolism, and Cardiovascular disease, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Aguila MB; Laboratory of Morphometry, Metabolism, and Cardiovascular disease, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: mbaguila@uerj.br.
Mandarim-de-Lacerda CA; Laboratory of Morphometry, Metabolism, and Cardiovascular disease, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: mandarim@uerj.br.

Life Sci ; 319: 121502, 2023 Apr 15.

Article em En | MEDLINE | ID: mdl-36796719

Assuntos

Diabetes Mellitus Tipo 2; Ilhotas Pancreáticas; Camundongos; Animais; Masculino; Camundongos Obesos; Fator A de Crescimento do Endotélio Vascular/metabolismo; Receptor do Peptídeo Semelhante ao Glucagon 1/metabolismo; Diabetes Mellitus Tipo 2/tratamento farmacológico; Diabetes Mellitus Tipo 2/metabolismo; Camundongos Endogâmicos C57BL; Ilhotas Pancreáticas/metabolismo; Peptídeos Semelhantes ao Glucagon/farmacologia; Matriz Extracelular/metabolismo; Polipeptídeo Amiloide das Ilhotas Pancreáticas/genética; Polipeptídeo Amiloide das Ilhotas Pancreáticas/metabolismo; Polipeptídeo Amiloide das Ilhotas Pancreáticas/farmacologia; Dieta

Palavras-chave

Beta-cell; Heparanase; Islet amyloid polypeptide; Perlecan; Syndecan

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2023 Tipo de documento: Article

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