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A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans.
Topalovic, Uros; Barclay, Sam; Ling, Chenkai; Alzuhair, Ahmed; Yu, Wenhao; Hokhikyan, Vahagn; Chandrakumar, Hariprasad; Rozgic, Dejan; Jiang, Wenlong; Basir-Kazeruni, Sina; Maoz, Sabrina L; Inman, Cory S; Stangl, Matthias; Gill, Jay; Bari, Ausaf; Fallah, Aria; Eliashiv, Dawn; Pouratian, Nader; Fried, Itzhak; Suthana, Nanthia; Markovic, Dejan.
Afiliação
  • Topalovic U; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Barclay S; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
  • Ling C; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Alzuhair A; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Yu W; Department of Electrical Engineering, King Saud University, Riyadh, Saudi Arabia.
  • Hokhikyan V; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Chandrakumar H; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Rozgic D; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Jiang W; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Basir-Kazeruni S; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Maoz SL; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Inman CS; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Stangl M; Medical Scientist Training Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Gill J; Department of Psychology, University of Utah, Salt Lake City, UT, USA.
  • Bari A; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
  • Fallah A; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
  • Eliashiv D; Medical Scientist Training Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Pouratian N; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Fried I; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Suthana N; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Markovic D; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Nat Neurosci ; 26(3): 517-527, 2023 03.
Article em En | MEDLINE | ID: mdl-36804647
ABSTRACT
Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Estimulação Encefálica Profunda / Dispositivos Eletrônicos Vestíveis / Transtornos Mentais Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Nat Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Estimulação Encefálica Profunda / Dispositivos Eletrônicos Vestíveis / Transtornos Mentais Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Nat Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos