Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aß and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain.

Sola, Emma; Moyano, Paula; Flores, Andrea; García, José Manuel; García, Jimena; Anadon, María José; Frejo, María Teresa; Pelayo, Adela; de la Cabeza Fernandez, Maria; Del Pino, Javier

Sola, Emma; Moyano, Paula; Flores, Andrea; García, José Manuel; García, Jimena; Anadon, María José; Frejo, María Teresa; Pelayo, Adela; de la Cabeza Fernandez, Maria; Del Pino, Javier.

Afiliação

Sola E; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: pmoyanocires@ucm.es.
Flores A; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
de la Cabeza Fernandez M; Department of Chemistry in Pharmaceutical Sciences, Pharmacy School, Complutense University of Madrid, 28041, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: jdelpino@pdi.ucm.es.

Chem Biol Interact ; 375: 110428, 2023 Apr 25.

Article em En | MEDLINE | ID: mdl-36868496

Assuntos

Prosencéfalo Basal; Cádmio; Animais; Masculino; Ratos; Secretases da Proteína Precursora do Amiloide/metabolismo; Ácido Aspártico Endopeptidases/metabolismo; Prosencéfalo Basal/metabolismo; Cádmio/toxicidade; Gliose/induzido quimicamente; Glicogênio Sintase Quinase 3 beta/metabolismo; Inflamação; Ratos Wistar; Espécies Reativas de Oxigênio; Proteínas tau/metabolismo; Hormônios Tireóideos

Palavras-chave

Aß and Tau proteins; Basal forebrain cholinergic neurons; Cadmium; Inflammatory cytokines; Oxidative stress; T3

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Cádmio / Prosencéfalo Basal Limite: Animals Idioma: En Revista: Chem Biol Interact Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha

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