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Risk factors associated with preterm birth in singletons born after IVF: a national cohort study.
Gervoise-Boyer, Marie-Josée; Fauque, Patricia; De Mouzon, Jacques; Devaux, Aviva; Epelboin, Sylvie; Levy, Rachel; Valentin, Morgane; Viot, Géraldine; Bonomini, Justine; Bergère, Marianne; Jonveaux, Philippe; Pessione, Fabienne.
Afiliação
  • Gervoise-Boyer MJ; Department of Reproductive Medicine and Biology, Hôpital Saint-Joseph, Marseille 8, France. Electronic address: boyermarie@gmail.com.
  • Fauque P; University of Bourgogne Franche-Comté - INSERM UMR1231, 2 Rue Angélique Ducoudray, F-21000 Dijon, France.
  • De Mouzon J; Unilabs, Medical Direction, Clichy-La-Garenne, France.
  • Devaux A; Centre for Medically Assisted Reproduction, Reproductive Biology, CHU Amiens-Picardie, France.
  • Epelboin S; Centre for Medically Assisted Reproduction, Obstetrics and Gynaecology, Reproductive Medicine, Université Paris 7 Diderot, Bichat Claude-Bernard Hospital Group, AP-HP, Paris, France.
  • Levy R; Inserm, Genetic and acquired lipodystrophies team, Reproductive Biology Department-CECOS, Saint-Antoine Research center, Sorbonne university, hôpital Tenon, AP-HP, 75020 Paris, France.
  • Valentin M; Antenatal diagnosis, obstetrics and gynaecology, Paris 7 Diderot university, Bichat Claude-Bernard Hospital group, AP-HP, Paris, France.
  • Viot G; Clinical Genetics Unit of La Muette 50 rue Nicolo 75116 Paris, France.
  • Bonomini J; Clinical Research Department, Hôpital Saint-Joseph, Marseille 8, France.
  • Bergère M; Agence de la biomédecine, 1 avenue du stade de France, 93212 La Plaine Saint Denis, France.
  • Jonveaux P; Agence de la biomédecine, 1 avenue du stade de France, 93212 La Plaine Saint Denis, France.
  • Pessione F; Agence de la biomédecine, 1 avenue du stade de France, 93212 La Plaine Saint Denis, France.
Reprod Biomed Online ; 46(4): 750-759, 2023 04.
Article em En | MEDLINE | ID: mdl-36868885
RESEARCH QUESTION: What are the risk factors for prematurity other than intrauterine growth restriction in singletons after IVF? DESIGN: Data were collected from a national registry, based on an observational prospective cohort of 30,737 live births after assisted reproductive technology (fresh embryo transfers: n = 20,932 and frozen embryo transfer [FET] n = 9805) between 2014 and 2015. A population of not-small for gestational age singletons conceived after fresh embryo transfers and FET, and their parents, was selected. Data on a number of variables were collected, including type of infertility, number of oocytes retrieved and vanishing twins. RESULTS: Preterm birth occurred in 7.7% (n = 1607) of fresh embryo transfers and 6.2% (n = 611) of frozen-thawed embryo transfers (P < 0.0001; adjusted odds ratio [aOR] = 1.34 [1.21-1.49]). Endometriosis and vanishing twin increased the risk of preterm birth after fresh embryo transfer (P < 0.001; aOR 1.32 and 1.78, respectively). Polycystic ovaries or more than 20 oocytes retrieved also increased preterm birth risk (aOR 1.31 and 1.30; P = 0.003 and P = 0.02, respectively); large oocyte cohort (>20) was no longer associated with the risk of prematurity in FET. CONCLUSION: Endometriosis remains a risk for prematurity even in the absence of intrauterine growth retardation, which suggests a dysimmune effect. Large oocyte cohorts obtained by stimulation, without clinical polycystic ovary syndrome diagnosed before attempts, do not affect FET outcomes, reinforcing the idea of a phenotypic difference in the clinical presentation of polycystic ovary syndrome.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Nascimento Prematuro / Endometriose Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Reprod Biomed Online Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Nascimento Prematuro / Endometriose Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Reprod Biomed Online Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2023 Tipo de documento: Article