[Determination of benzopyrene-hydroxylase (cytochrome P-450) activity in patients with lung cancer]. / Opredelenie aktivnosti fermenta benzpiren-gidroksilazy (tsitokhrom P-450) u bol'nykh rakom legkogo.

ABSTRACT

The study was concerned with comparison of inducibility index (ii) for benzopyrene-hydroxylase in mitogen-activated lymphocytes in patients with primary cancer of the lung, other cancers (breast, stomach, lower lip, rectum, skin and thyroid gland) and in lymphocytes of blood donors. The highest ii values were registered in bronchogenic carcinoma patients. Smokers, both lung cancer patients and healthy donors, revealed high values (80.0 and 83.3%, respectively). A modified "lymphocytic test" to assess the risk factor for primary lung cancer is suggested.