Diseases of Hereditary Renal Cell Cancers.
Urol Clin North Am
; 50(2): 205-215, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-36948667
ABSTRACT
Germline mutations in tumor suppressor genes and oncogenes lead to hereditary renal cell carcinoma (HRCC) diseases, characterized by a high risk of RCC and extrarenal manifestations. Patients of young age, those with a family history of RCC, and/or those with a personal and family history of HRCC-related extrarenal manifestations should be referred for germline testing. Identification of a germline mutation will allow for testing of family members at risk, as well as personalized surveillance programs to detect the early onset of HRCC-related lesions. The latter allows for more targeted and therefore more effective therapy and better preservation of renal parenchyma.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Síndromes Neoplásicas Hereditárias
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Carcinoma de Células Renais
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Neoplasias Renais
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Urol Clin North Am
Ano de publicação:
2023
Tipo de documento:
Article