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Challenges and opportunities for modeling aging and cancer.
Anczuków, Olga; Airhart, Susie; Chuang, Jeffrey H; Coussens, Lisa M; Kuchel, George A; Korstanje, Ron; Li, Sheng; Lucido, Anna Lisa; McAllister, Sandra S; Politi, Katerina; Polyak, Kornelia; Ratliff, Timothy; Ren, Gary; Trowbridge, Jennifer J; Ucar, Duygu; Palucka, Karolina.
Afiliação
  • Anczuków O; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. Electronic address: olga.anczukow@jax.org.
  • Airhart S; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
  • Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  • Coussens LM; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
  • Kuchel GA; UConn Center on Aging, University of Connecticut School of Medicine, Farmington, CT, USA.
  • Korstanje R; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
  • Li S; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  • Lucido AL; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  • McAllister SS; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA.
  • Politi K; Departments of Pathology, and Medicine (Section of Medical Oncology), Yale School of Medicine and Yale Cancer Center, New Haven, CT, USA.
  • Polyak K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA; The Ludwig Center at Harv
  • Ratliff T; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.
  • Ren G; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
  • Trowbridge JJ; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
  • Ucar D; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  • Palucka K; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. Electronic address: karolina.palucka@jax.org.
Cancer Cell ; 41(4): 641-645, 2023 04 10.
Article em En | MEDLINE | ID: mdl-37001528
ABSTRACT
Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Envelhecimento / Neoplasias Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Envelhecimento / Neoplasias Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article