Challenges and opportunities for modeling aging and cancer.
Cancer Cell
; 41(4): 641-645, 2023 04 10.
Article
em En
| MEDLINE
| ID: mdl-37001528
ABSTRACT
Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Neoplasias
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Cancer Cell
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2023
Tipo de documento:
Article