In silico investigation of the structural stability as the origin of the pathogenicity of <i>&#945;</i>-synuclein protofibrils.

Yoon, Jeseong; Lee, MinJun; Park, Yunsu; Lee, Kyunghee; Shin, Seokmin

In silico investigation of the structural stability as the origin of the pathogenicity of α-synuclein protofibrils.

Yoon, Jeseong; Lee, MinJun; Park, Yunsu; Lee, Kyunghee; Shin, Seokmin.

Afiliação

Yoon J; Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
Lee M; Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
Park Y; Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
Lee K; Department of Chemistry, Sejong University, Seoul, Republic of Korea.
Shin S; Department of Chemistry, Seoul National University, Seoul, Republic of Korea.

J Biomol Struct Dyn ; 41(23): 14103-14115, 2023.

Article em En | MEDLINE | ID: mdl-37036430

Assuntos

Doença de Parkinson; alfa-Sinucleína; Humanos; alfa-Sinucleína/química; Virulência; Simulação de Dinâmica Molecular; Amiloide/química

Palavras-chave

MD simulation; Parkinson's disease; amyloid polymorphism; steric zipper; α-synuclein

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doença de Parkinson / Alfa-Sinucleína Limite: Humans Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2023 Tipo de documento: Article

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