The Burden of Human Bocavirus 1 in Hospitalized Children With Respiratory Tract Infections.
J Pediatric Infect Dis Soc
; 12(5): 282-289, 2023 May 31.
Article
em En
| MEDLINE
| ID: mdl-37099765
ABSTRACT
BACKGROUND:
Human bocavirus 1 (HBoV1) is frequently codetected with other viruses, and detected in asymptomatic children. Thus, the burden of HBoV1 respiratory tract infections (RTI) has been unknown. Using HBoV1-mRNA to indicate true HBoV1 RTI, we assessed the burden of HBoV1 in hospitalized children and the impact of viral codetections, compared with respiratory syncytial virus (RSV).METHODS:
Over 11 years, we enrolled 4879 children <16 years old admitted with RTI. Nasopharyngeal aspirates were analyzed with polymerase chain reaction for HBoV1-DNA, HBoV1-mRNA, and 19 other pathogens.RESULTS:
HBoV1-mRNA was detected in 2.7% (130/4850) samples, modestly peaking in autumn and winter. Forty-three percent with HBoV1 mRNA were 12-17 months old, and only 5% were <6 months old. A total of 73.8% had viral codetections. It was more likely to detect HBoV1-mRNA if HBoV1-DNA was detected alone (odds ratio [OR] 3.9, 95% confidence interval [CI] 1.7-8.9) or with 1 viral codetection (OR 1.9, 95% CI 1.1-3.3), compared to ≥2 codetections. Codetection of severe viruses like RSV had lower odds for HBoV1-mRNA (OR 0.34, 95% CI 0.19-0.61). The yearly lower RTI hospitalization rate per 1000 children <5 years was 0.7 for HBoV1-mRNA and 8.7 for RSV.CONCLUSIONS:
True HBoV1 RTI is most likely when HBoV1-DNA is detected alone, or with 1 codetected virus. Hospitalization due to HBoV1 LRTI is 10-12 times less common than RSV.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Bocavirus Humano
/
Hospitalização
Tipo de estudo:
Diagnostic_studies
Limite:
Child
/
Humans
Idioma:
En
Revista:
J Pediatric Infect Dis Soc
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Noruega