Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines.

Kairuz, Dylan; Samudh, Nazia; Ely, Abdullah; Arbuthnot, Patrick; Bloom, Kristie

Kairuz, Dylan; Samudh, Nazia; Ely, Abdullah; Arbuthnot, Patrick; Bloom, Kristie.

Afiliação

Kairuz D; Wits/SAMRC Antiviral Gene Therapy Research Unit, Infectious Diseases and Oncology Research Institute (IDORI), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.
Samudh N; Wits/SAMRC Antiviral Gene Therapy Research Unit, Infectious Diseases and Oncology Research Institute (IDORI), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.
Ely A; Wits/SAMRC Antiviral Gene Therapy Research Unit, Infectious Diseases and Oncology Research Institute (IDORI), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.
Arbuthnot P; Wits/SAMRC Antiviral Gene Therapy Research Unit, Infectious Diseases and Oncology Research Institute (IDORI), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.
Bloom K; Wits/SAMRC Antiviral Gene Therapy Research Unit, Infectious Diseases and Oncology Research Institute (IDORI), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.

Pharmaceutics ; 15(4)2023 Apr 07.

Article em En | MEDLINE | ID: mdl-37111658

Palavras-chave

LNP characterization; LNP production; RNA delivery; RNA vaccines; cationic lipid nanoparticles; lipid film hydration; microfluidics; saRNA

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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: Pharmaceutics Ano de publicação: 2023 Tipo de documento: Article País de afiliação: África do Sul

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