Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir.

Kawajiri, Takahiro; Kijima, Akihito; Iimuro, Atsuhiro; Ohashi, Eisaku; Yamakawa, Katsuya; Agura, Kazushi; Masuda, Kengo; Kouki, Kensuke; Kasamatsu, Koji; Yanagisawa, Shuichi; Nakashima, Sho; Shibahara, Setsuya; Toyota, Takashi; Higuchi, Takafumi; Suto, Takahiro; Oohara, Tadashi; Maki, Toshikatsu; Sahara, Naoto; Fukui, Nobuaki; Wakamori, Hisayuki; Ikemoto, Hidaka; Murakami, Hiroaki; Ando, Hiroyasu; Hosoya, Masahiro; Sato, Mizuki; Suzuki, Yusuke; Nakagawa, Yuta; Unoh, Yuto; Hirano, Yoichi; Nagasawa, Yoshitomo; Goda, Satoshi; Ohara, Takafumi; Tsuritani, Takayuki

Kawajiri, Takahiro; Kijima, Akihito; Iimuro, Atsuhiro; Ohashi, Eisaku; Yamakawa, Katsuya; Agura, Kazushi; Masuda, Kengo; Kouki, Kensuke; Kasamatsu, Koji; Yanagisawa, Shuichi; Nakashima, Sho; Shibahara, Setsuya; Toyota, Takashi; Higuchi, Takafumi; Suto, Takahiro; Oohara, Tadashi; Maki, Toshikatsu; Sahara, Naoto; Fukui, Nobuaki; Wakamori, Hisayuki; Ikemoto, Hidaka; Murakami, Hiroaki; Ando, Hiroyasu; Hosoya, Masahiro; Sato, Mizuki; Suzuki, Yusuke; Nakagawa, Yuta; Unoh, Yuto; Hirano, Yoichi; Nagasawa, Yoshitomo; Goda, Satoshi; Ohara, Takafumi; Tsuritani, Takayuki.

Afiliação

Kawajiri T; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Kijima A; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Iimuro A; Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-Chome, Toyonaka, Osaka 561-0825, Japan.
Ohashi E; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Yamakawa K; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Agura K; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Masuda K; Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-Chome, Toyonaka, Osaka 561-0825, Japan.
Kouki K; Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-Chome, Toyonaka, Osaka 561-0825, Japan.
Kasamatsu K; Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-Chome, Toyonaka, Osaka 561-0825, Japan.
Yanagisawa S; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Nakashima S; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Shibahara S; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Toyota T; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Higuchi T; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Suto T; Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-Chome, Toyonaka, Osaka 561-0825, Japan.
Oohara T; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Maki T; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Sahara N; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Fukui N; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Wakamori H; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Ikemoto H; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Murakami H; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Ando H; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Hosoya M; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Sato M; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Suzuki Y; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Nakagawa Y; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Unoh Y; Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-Chome, Toyonaka, Osaka 561-0825, Japan.
Hirano Y; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Nagasawa Y; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Goda S; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Ohara T; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.
Tsuritani T; API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan.

ACS Cent Sci ; 9(4): 836-843, 2023 Apr 26.

Article em En | MEDLINE | ID: mdl-37122445

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: ACS Cent Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão