Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging.
Annu Rev Immunol
; 41: 181-205, 2023 04 26.
Article
em En
| MEDLINE
| ID: mdl-37126417
There is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells that gain proinflammatory features. Importantly, all of these subsets lose their lymph node homing capacity and migrate preferentially to nonlymphoid tissues, where they contribute to tissue deterioration and inflammaging.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Subpopulações de Linfócitos T
Limite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Immunol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Espanha