<i>In silico</i> mutation of aromatic with aliphatic amino acid residues in <i>Clostridium perfringens</i> epsilon toxin (ETX) reduces its binding efficiency to Caprine Myelin and lymphocyte (MAL) protein receptors.

Kumar, Sunil; Behera, Santosh Kumar; Gururaj, Kumaresan; Chaurasia, Anurag; Murmu, Sneha; Prabha, Ratna; Angadi, U B; Pawaiya, Rajveer Singh; Rai, Anil

In silico mutation of aromatic with aliphatic amino acid residues in Clostridium perfringens epsilon toxin (ETX) reduces its binding efficiency to Caprine Myelin and lymphocyte (MAL) protein receptors.

Kumar, Sunil; Behera, Santosh Kumar; Gururaj, Kumaresan; Chaurasia, Anurag; Murmu, Sneha; Prabha, Ratna; Angadi, U B; Pawaiya, Rajveer Singh; Rai, Anil.

Afiliação

Kumar S; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.
Behera SK; National Institute of Pharmaceutical Education and Research, Ahmedabad, India.
Gururaj K; ICAR-Central Institute for Research on Goats, Makhdoom, Mathura, India.
Chaurasia A; ICAR-Indian Institute of Vegetable Research, Varanasi, India.
Murmu S; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.
Prabha R; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.
Angadi UB; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.
Pawaiya RS; ICAR-Central Institute for Research on Goats, Makhdoom, Mathura, India.
Rai A; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.

J Biomol Struct Dyn ; 42(5): 2257-2269, 2024 Mar.

Article em En | MEDLINE | ID: mdl-37129165

Assuntos

Toxinas Bacterianas; Clostridium perfringens; Bainha de Mielina; Animais; Aminoácidos/metabolismo; Clostridium perfringens/genética; Clostridium perfringens/metabolismo; Enterotoxemia; Cabras; Linfócitos; Mutação; Proteínas da Mielina/genética; Proteínas Proteolipídicas Associadas a Linfócitos e Mielina/metabolismo; Toxinas Bacterianas/genética; Toxinas Bacterianas/metabolismo

Palavras-chave

Epsilon toxin (ETX); MAL protein; enterotoxaemia (ET); molecular dynamics; protein-protein interactions

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Toxinas Bacterianas / Clostridium perfringens / Bainha de Mielina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia

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