Pathogenic HER3 dimerization domain mutations create a structural bias towards un-conventional EGFR-HER3 signalling axis in breast cancer.

Dey, Pranay; Gadewal, Nikhil; De, Abhijit

Dey, Pranay; Gadewal, Nikhil; De, Abhijit.

Afiliação

Dey P; Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India; Faculty of Life Sciences, Homi Bhabha National Institute, Mumbai, India.
Gadewal N; Bioinformatics unit, ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai, India.
De A; Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India; Faculty of Life Sciences, Homi Bhabha National Institute, Mumbai, India. Electronic address: ade@actrec.gov.in.

Int J Biol Macromol ; 242(Pt 2): 124765, 2023 Jul 01.

Article em En | MEDLINE | ID: mdl-37156315

Assuntos

Neoplasias da Mama; Receptor ErbB-3; Feminino; Humanos; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Dimerização; Receptores ErbB/genética; Receptores ErbB/metabolismo; Mutação; Neuregulina-1/genética; Neuregulina-1/metabolismo; Neuregulina-1/farmacologia; Receptor ErbB-2/metabolismo; Receptor ErbB-3/genética; Receptor ErbB-3/metabolismo

Palavras-chave

HER2; HER3; Receptor switching

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias da Mama / Receptor ErbB-3 Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia

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