New insights into follicular regulatory T cells in the intestinal and tumor microenvironments.
J Cell Physiol
; 238(7): 1465-1477, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37210730
ABSTRACT
Follicular regulatory T (Tfr) cells are a novel and unique subset of effector regulatory T (Treg) cells that are located in germinal centers (GCs). Tfr cells express transcription profiles that are characteristic of both follicular helper T (Tfh) cells and Treg cells and negatively regulate GC reactions, including Tfh cell activation and cytokine production, class switch recombination and B cell activation. Evidence also shows that Tfr cells have specific characteristics in different local immune microenvironments. This review focuses on the regulation of Tfr cell differentiation and function in unique local immune microenvironments, including the intestine and tumor.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Linfócitos T Reguladores
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Microambiente Tumoral
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Intestinos
Idioma:
En
Revista:
J Cell Physiol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China