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Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibody Responses After Community Infections in Children and Adults.
Dawood, Fatimah S; Couture, Alexia; Zhang, Xueyan; Stockwell, Melissa S; Porucznik, Christina A; Stanford, Joseph B; Hetrich, Marissa; Veguilla, Vic; Thornburg, Natalie; Heaney, Christopher D; Wang, Jing; Duque, Jazmin; Jeddy, Zuha; Deloria Knoll, Maria; Karron, Ruth.
Afiliação
  • Dawood FS; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Couture A; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Zhang X; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Stockwell MS; Division of Child and Adolescent Health, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.
  • Porucznik CA; Department of Population and Family Health, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York, USA.
  • Stanford JB; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Hetrich M; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Veguilla V; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Thornburg N; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Heaney CD; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Wang J; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Duque J; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Jeddy Z; Abt Associates, Cambridge, Massachusetts, USA.
  • Deloria Knoll M; Abt Associates, Cambridge, Massachusetts, USA.
  • Karron R; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Open Forum Infect Dis ; 10(5): ofad168, 2023 May.
Article em En | MEDLINE | ID: mdl-37213425
Background: We compared postinfection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (nAb) responses among children and adults while the D614G-like strain and Alpha, Iota, and Delta variants circulated. Methods: During August 2020-October 2021, households with adults and children were enrolled and followed in Utah, New York City, and Maryland. Participants collected weekly respiratory swabs that were tested for SARS-CoV-2 and had sera collected during enrollment and follow-up. Sera were tested for SARS-CoV-2 nAb by pseudovirus assay. Postinfection titers were characterized with biexponential decay models. Results: Eighty participants had SARS-CoV-2 infection during the study (47 with D614G-like virus, 17 with B.1.1.7, and 8 each with B.1.617.2 and B.1.526 virus). Homologous nAb geometric mean titers (GMTs) trended higher in adults (GMT = 2320) versus children 0-4 (GMT = 425, P = .33) and 5-17 years (GMT = 396, P = .31) at 1-5 weeks postinfection but were similar from 6 weeks. Timing of peak titers was similar by age. Results were consistent when participants with self-reported infection before enrollment were included (n = 178). Conclusions: The SARS-CoV-2 nAb titers differed in children compared to adults early after infection but were similar by 6 weeks postinfection. If postvaccination nAb kinetics have similar trends, vaccine immunobridging studies may need to compare nAb responses in adults and children 6 weeks or more after vaccination.
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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos