Exosomal miR-218 derived from mesenchymal stem cells inhibits endothelial-to-mesenchymal transition by epigenetically modulating of BMP2 in pulmonary fibrosis.

Zhao, Yuhao; Du, Lei; Sun, Jiali; Wang, Xuelian; Cong, Zhilei; Chen, Shuyan; Wang, Fei; Li, Zhen

Zhao, Yuhao; Du, Lei; Sun, Jiali; Wang, Xuelian; Cong, Zhilei; Chen, Shuyan; Wang, Fei; Li, Zhen.

Afiliação

Zhao Y; Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.
Du L; Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.
Sun J; Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.
Wang X; Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.
Cong Z; Department of Emergency, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Chen S; Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. chenshuyan@xinhuamed.com.cn.
Wang F; Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. wangfei01@xinhuamed.com.cn.
Li Z; Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. lizhen8367@xinhuamed.com.cn.

Cell Biol Toxicol ; 39(6): 2919-2936, 2023 12.

Article em En | MEDLINE | ID: mdl-37247103

Assuntos

Células-Tronco Mesenquimais; MicroRNAs; Fibrose Pulmonar; Humanos; Fibrose Pulmonar/induzido quimicamente; Fibrose Pulmonar/genética; Fibrose Pulmonar/metabolismo; Células Endoteliais/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Fibrose; MicroRNAs/metabolismo; Células-Tronco Mesenquimais/metabolismo; Proteína Morfogenética Óssea 2/genética; Proteína Morfogenética Óssea 2/metabolismo

Palavras-chave

Endothelial-to-mesenchymal transition; Exosome; Idiopathic pulmonary fibrosis; MicroRNA; TGF-ß

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fibrose Pulmonar / MicroRNAs / Células-Tronco Mesenquimais Limite: Humans Idioma: En Revista: Cell Biol Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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