Template-jumping prime editing enables large insertion and exon rewriting in vivo.

Zheng, Chunwei; Liu, Bin; Dong, Xiaolong; Gaston, Nicholas; Sontheimer, Erik J; Xue, Wen

Zheng, Chunwei; Liu, Bin; Dong, Xiaolong; Gaston, Nicholas; Sontheimer, Erik J; Xue, Wen.

Afiliação

Zheng C; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Liu B; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Dong X; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Gaston N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Sontheimer EJ; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. erik.sontheimer@umassmed.edu.
Xue W; Department of Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. erik.sontheimer@umassmed.edu.

Nat Commun ; 14(1): 3369, 2023 06 08.

Article em En | MEDLINE | ID: mdl-37291100

Assuntos

DNA; Edição de Genes; Camundongos; Animais; DNA/metabolismo; Quebras de DNA de Cadeia Dupla; Éxons/genética; Genoma; Sistemas CRISPR-Cas/genética

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: DNA / Edição de Genes Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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