Alkylation of <i>N</i>H-sulfoximines under Mitsunobu-type conditions.

Dodd, Cayden J; Schultz, Daniel C; Li, Jinming; Lindsley, Craig W; Bender, Aaron M

Alkylation of NH-sulfoximines under Mitsunobu-type conditions.

Dodd, Cayden J; Schultz, Daniel C; Li, Jinming; Lindsley, Craig W; Bender, Aaron M.

Afiliação

Dodd CJ; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, 393 Nichol Mill Lane, Franklin, TN, 37067, USA. aaron.bender@vanderbilt.edu.
Schultz DC; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, 393 Nichol Mill Lane, Franklin, TN, 37067, USA. aaron.bender@vanderbilt.edu.
Li J; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, 393 Nichol Mill Lane, Franklin, TN, 37067, USA. aaron.bender@vanderbilt.edu.
Lindsley CW; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, 393 Nichol Mill Lane, Franklin, TN, 37067, USA. aaron.bender@vanderbilt.edu.
Bender AM; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, 393 Nichol Mill Lane, Franklin, TN, 37067, USA. aaron.bender@vanderbilt.edu.

Org Biomol Chem ; 21(25): 5181-5184, 2023 Jun 28.

Article em En | MEDLINE | ID: mdl-37293894

ABSTRACT

ABSTRACT

Previously described approaches for the alkylation of NH-sulfoximines typically rely either on transition metal catalysis, or the use of traditional alkylation reagents and strong bases. Herein, we report a straightforward alkylation of diverse NH-sulfoximines under simple Mitsunobu-type conditions, despite the unusually high pKa of the NH center.

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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