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The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia.
Kusumawati, Maya; Koesoemadinata, Raspati Cundarani; Fatma, Zuhaira Husna; Susandi, Evan; Permana, Hikmat; Soetedjo, Nanny Natalia Mulyani; Soeroto, Arto Yuwono; Bestari, Begawan; Andriyoko, Basti; Alisjahbana, Bachti; Hartantri, Yovita.
Afiliação
  • Kusumawati M; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Dr Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.
  • Koesoemadinata RC; Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
  • Fatma ZH; Indonesian Society for Clinical Microbiology, Jakarta, Indonesia.
  • Susandi E; Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
  • Permana H; Department of Internal Medicine, Faculty of Medicine, Dr Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.
  • Soetedjo NNM; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Dr Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.
  • Soeroto AY; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Dr Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.
  • Bestari B; Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
  • Andriyoko B; Respirology and Critical Illness Division, Department of Internal Medicine, Faculty of Medicine, Dr Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.
  • Alisjahbana B; Division of Gastroentero Hepatology, Department of Internal Medicine, Faculty of Medicine, Dr Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.
  • Hartantri Y; Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
PLoS One ; 18(6): e0286797, 2023.
Article em En | MEDLINE | ID: mdl-37319126
Immune system dysregulation in people with diabetes mellitus (DM) increases the risk of acquiring severe infection. We compared the clinical characteristics and laboratory parameters of coronavirus disease 2019 (COVID-19) patients with and without DM and estimated the effect of DM on mortality among COVID-19 patients. A retrospective cohort study collecting patients' demographic, clinical characteristics, laboratory parameters and treatment outcomes from medical records was conducted in a hospital in Bandung City from March to December 2020. Univariable and multivariable logistic regression was performed to determine the association between DM and death. A total of 664 COVID-19 patients with positive real-time reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 were included in this study, of whom 147 were with DM. Half of DM patients presented HbA1c ≥10%. DM patients were more likely to present with comorbidities and severe to critical conditions at admission (P <0.001). Laboratory parameters such as neutrophil-lymphocyte count ratio, C-reactive protein, D-dimer, ferritin, and lactate dehydrogenase were higher in the DM group. In the univariate analysis, variables associated with death were COVID-19 severity at baseline, neurologic disease, DM, age ≥60 years, hypertension, cardiovascular disease, and chronic kidney disease. DM remained associated with death (aOR 1.82; 95% CI 1.13-2.93) after adjustment with sex, age, hypertension, cardiovascular disease, and chronic kidney disease. In conclusion, COVID-19 patients with DM are more likely to present with a very high HbA1c, comorbidities, and severe-critical illness. Chronic inflammation in DM patients may be aggravated by the disruption of immune response caused by COVID-19, leading to worse laboratory results and poor outcomes.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Diabetes Mellitus / Insuficiência Renal Crônica / COVID-19 / Hipertensão Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans / Middle aged País/Região como assunto: Asia Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Indonésia

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Diabetes Mellitus / Insuficiência Renal Crônica / COVID-19 / Hipertensão Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans / Middle aged País/Região como assunto: Asia Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Indonésia