Serum Amyloid A: A Potential New Marker of Severity in Hidradenitis Suppurativa.
Skin Appendage Disord
; 9(3): 165-168, 2023 Jun.
Article
em En
| MEDLINE
| ID: mdl-37325280
ABSTRACT
Introduction:
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with systemic inflammation and high impact on quality of life. Treatment strategies are still inadequate with a lack of inflammation biomarkers. We conducted a prospective study to assess the correlation between serum amyloid A (SAA) levels and active lesion count; disease severity; Dermatology Life Quality Index (DLQI); smoking; BMI; and lesion sites.Methods:
Forty-one patients (M/F 22/19) were enrolled. Demographic, clinical, laboratory, and therapeutic data were assessed at baseline on patients not under treatment or in wash-out from systemic treatment for at least 2 weeks. Associations were investigated by univariate and multivariate analyses.Results:
SAA levels were significantly associated with number of nodules (p = 0.005), abscesses (p < 0.001), fistulas (p = 0.016), and severe IHS4 (p = 0.088 and r = 0.514). Gluteal localization was correlated with high values of mSartorius and severe IHS4.Conclusions:
We recommend assessment of SAA levels to monitor therapeutic response in patient with HS in order to prevent disease's flare and potential complications.
Texto completo:
1
Bases de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Skin Appendage Disord
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália