Air pollution exposure is associated with rhinitis in older US adults via specific immune mechanisms.
Int Forum Allergy Rhinol
; 14(1): 68-77, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37357822
ABSTRACT
BACKGROUND:
Pathophysiology of rhinitis in older adults is largely unknown. We tested whether air pollution is associated with this condition and how immune mechanisms may play a role in this relationship.METHODS:
We analyzed cross-sectional data from the National Social Life, Health, and Aging Project, a nationally representative study of older adults born between 1920 and 1947. Particulate matter ≤2.5 µm (PM2.5 ) air pollution exposure estimates were generated using validated spatiotemporal models. Presence of rhinitis was defined based on medication use (≥1 intranasal medications steroids, antihistamines, lubricants, and/or decongestants, and/or oral medications antihistamines and/or decongestants). K-means cluster analysis (Jaccard method) was used to group 13 peripheral blood cytokines into 3 clusters to facilitate functional determination. We fitted multivariate logistic regressions to correlate PM2.5 exposure with presence of rhinitis, controlling for confounders, and then determined the role of cytokines in this relationship.RESULTS:
Long- (but not short-) term exposure to PM2.5 was associated with presence of rhinitis 3-year exposure window, odds ratio (OR) = 1.32, 95% confidence interval (CI) 0.98, 1.80, per 1 standard deviation (SD) PM2.5 increase. Inclusion of cytokine cluster in the model led to a modestly stronger effect of PM2.5 exposure on rhinitis (OR = 1.37; 95% CI 1.00, 1.87; 3-year exposure window). The particular immune profile responsible for this result was composed of elevated IL-3, IL-12, and IFN-γ (OR = 4.86, 95% CI 1.10, 21.58, immune profile-PM2.5 exposure interaction term).CONCLUSION:
We show for the first time that IL-3, IL-12, and IFN-γ explain in part the relationship between PM2.5 exposure and rhinitis in older US adults. If confirmed, these immune pathways may be used as therapeutic targets.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Rinite
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Poluentes Atmosféricos
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Poluição do Ar
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Aged
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Humans
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Middle aged
Idioma:
En
Revista:
Int Forum Allergy Rhinol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos