Synthesis and inhibitory activity of euparin derivatives as potential dual inhibitors against &#945;-glucosidase and protein tyrosine phosphatase 1B (PTP1B).

Wang, Jinqiang; Feng, Dandan; Xiang, Yimin; Guo, Ji; Huang, Nianyu; Yu, Na; Yang, Huishu; Liu, Chengxiong; Zou, Kun

Synthesis and inhibitory activity of euparin derivatives as potential dual inhibitors against α-glucosidase and protein tyrosine phosphatase 1B (PTP1B).

Wang, Jinqiang; Feng, Dandan; Xiang, Yimin; Guo, Ji; Huang, Nianyu; Yu, Na; Yang, Huishu; Liu, Chengxiong; Zou, Kun.

Afiliação

Wang J; Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.
Feng D; Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.
Xiang Y; Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.
Guo J; Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.
Huang N; Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.
Yu N; Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.
Yang H; Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.
Liu C; Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.. Electronic address: liuchengxiong666@126.com.
Zou K; Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.. Electronic address: kzou@ctgu.edu.cn.

Fitoterapia ; 169: 105596, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37364700

Assuntos

Diabetes Mellitus Tipo 2; Inibidores de Glicosídeo Hidrolases; Humanos; Inibidores de Glicosídeo Hidrolases/farmacologia; Inibidores de Glicosídeo Hidrolases/química; Inibidores Enzimáticos/farmacologia; Inibidores Enzimáticos/química; Diabetes Mellitus Tipo 2/tratamento farmacológico; alfa-Glucosidases/metabolismo; Estrutura Molecular; Proteína Tirosina Fosfatase não Receptora Tipo 1; Simulação de Acoplamento Molecular

Palavras-chave

Chalcone; Diabetes; Euparin; Molecular docking; PTP1B; α-Glucosidase

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Inibidores de Glicosídeo Hidrolases Limite: Humans Idioma: En Revista: Fitoterapia Ano de publicação: 2023 Tipo de documento: Article

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