Translational Models in Glioma Immunotherapy Research.
Curr Oncol
; 30(6): 5704-5718, 2023 06 11.
Article
em En
| MEDLINE
| ID: mdl-37366911
ABSTRACT
Immunotherapy is a promising therapeutic domain for the treatment of gliomas. However, clinical trials of various immunotherapeutic modalities have not yielded significant improvements in patient survival. Preclinical models for glioma research should faithfully represent clinically observed features regarding glioma behavior, mutational load, tumor interactions with stromal cells, and immunosuppressive mechanisms. In this review, we dive into the common preclinical models used in glioma immunology, discuss their advantages and disadvantages, and highlight examples of their utilization in translational research.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Glioma
Limite:
Humans
Idioma:
En
Revista:
Curr Oncol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos