A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept.

Sugiyama, Yuichi; Aoki, Yasunori

Sugiyama, Yuichi; Aoki, Yasunori.

Afiliação

Sugiyama Y; Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Josai International University, Chiyoda-ku, Tokyo, Japan (Y.A., Y.S.); ShanghaiTech University, iHuman Institute, Pudong, Shanghai, China (Y.S.); and Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden (Y.A.) y-sugiyama@jiu.ac.jp.
Aoki Y; Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Josai International University, Chiyoda-ku, Tokyo, Japan (Y.A., Y.S.); ShanghaiTech University, iHuman Institute, Pudong, Shanghai, China (Y.S.); and Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden (Y.A.).

Drug Metab Dispos ; 51(9): 1067-1076, 2023 09.

Article em En | MEDLINE | ID: mdl-37407092

Assuntos

Hepatócitos; Modelos Biológicos; Hepatócitos/metabolismo; Cinética; Fígado/metabolismo; Albuminas/metabolismo

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Hepatócitos / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article

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