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Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL-286, a novel retinoic acid receptor-ß agonist for treatment of spinal cord injury, in male healthy participants.
Goncalves, Maria B; Mant, Tim; Täubel, Jörg; Clarke, Earl; Hassanin, Hana; Bendel, Daryl; Fok, Henry; Posner, John; Holmes, Jane; Mander, Adrian P; Corcoran, Jonathan P T.
Afiliação
  • Goncalves MB; Neuroscience Drug Discovery Unit, The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, UK.
  • Mant T; NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Täubel J; Richmond Pharmacology Limited, London, UK.
  • Clarke E; Neuroscience Drug Discovery Unit, The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, UK.
  • Hassanin H; Surrey Clinical Research Centre, University of Surrey, Surrey, UK.
  • Bendel D; Surrey Clinical Research Centre, University of Surrey, Surrey, UK.
  • Fok H; NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Posner J; Centre for Pharmaceutical Medicine Research, Institute of Pharmaceutical Science, King's College London, London, UK.
  • Holmes J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Mander AP; Centre for Trials Research, Cardiff University, Cardiff, UK.
  • Corcoran JPT; Neuroscience Drug Discovery Unit, The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, UK.
Br J Clin Pharmacol ; 89(12): 3573-3583, 2023 12.
Article em En | MEDLINE | ID: mdl-37452623
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Drogas em Investigação / Receptores do Ácido Retinoico Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans / Male Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Drogas em Investigação / Receptores do Ácido Retinoico Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans / Male Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido