Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.

Joshi, Pallavi R; Sadre, Shayan; Guo, Xiaoyan A; McCoy, Jason G; Mootha, Vamsi K

Joshi, Pallavi R; Sadre, Shayan; Guo, Xiaoyan A; McCoy, Jason G; Mootha, Vamsi K.

Afiliação

Joshi PR; Broad Institute, Cambridge, Massachusetts, USA; Department of Molecular Biology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Sadre S; Broad Institute, Cambridge, Massachusetts, USA; Department of Molecular Biology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Guo XA; Broad Institute, Cambridge, Massachusetts, USA; Department of Molecular Biology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
McCoy JG; Broad Institute, Cambridge, Massachusetts, USA; Department of Molecular Biology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Mootha VK; Broad Institute, Cambridge, Massachusetts, USA; Department of Molecular Biology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: vamsi@hms.harvard.edu.

J Biol Chem ; 299(9): 105075, 2023 09.

Article em En | MEDLINE | ID: mdl-37481209

Assuntos

Ferredoxinas; Lipoilação; Humanos; Ferredoxinas/genética; Ferredoxinas/metabolismo; Ácido Tióctico/metabolismo; Hipóxia Celular/efeitos dos fármacos; Técnicas de Inativação de Genes; Oxigênio/farmacologia; Proteoma/efeitos dos fármacos; Proteoma/genética; Sulfurtransferases/genética; Sulfurtransferases/metabolismo; Sítios de Ligação; Estabilidade Proteica; Biossíntese de Proteínas/efeitos dos fármacos

Palavras-chave

SAM; energy metabolism; hypoxia; ironsulfur protein; lipoate; mitochondria

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Lipoilação / Ferredoxinas Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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